Ivabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice

Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperitoneally (i.p.), 10 minutes before each PTZ injection till the end of the schedule. Seizure score, latency and duration were recorded in all groups. Nitrite, malondialdehyde and reduced glutathione levels were assessed in brain homogenate at the end of schedule.